Daily low-dose tadalafil produces a different pharmacodynamic profile than higher intermittent dosing.
With continuous administration:
- Plasma concentrations remain stable
- Endothelial function may improve over time
- Sexual activity does not require advance planning
- Spontaneity is preserved
By contrast, higher as-needed doses produce a transient peak effect tied to a specific window.
Daily therapy is generally more appropriate for men with frequent sexual activity or persistent erectile dysfunction. As-needed therapy may be preferable for those with infrequent sexual encounters or who do not want continuous exposure.
Choice of regimen should be based on frequency of sexual activity, side effect tolerance, cardiovascular profile, and individual response.


