Safety Information

Tadalafil

You must always read this safety information prior to starting this medication and whenever you get a refill. There may be new information. This information is not a substitute for discussing your medical condition or treatment with your healthcare provider. It is only available if prescribed by a licensed physician partner through BraveRx who will determine if treatment is suitable.

What I need to know about Tadalafil:

Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor FDA-approved for treating erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). It works by increasing blood flow to the penis to help achieve and maintain an erection.

Absolute Contraindications - DO NOT use tadalafil if you:

  • Are allergic to tadalafil or its ingredients
  • Are taking any form of nitrate medication for chest pain or heart problems
  • Are taking guanylate cyclase stimulators like riociguat

Drug Interactions - DO NOT use tadalafil if you take:

  • Nitrate medications like nitroglycerin, isosorbide, or recreational "poppers"
  • Guanylate cyclase stimulators like riociguat
  • Certain HIV protease inhibitors like ritonavir without dose adjustments

Serious Side Effects - STOP treatment and seek emergency care if you experience:

  • Sudden vision loss in one or both eyes
  • Sudden decrease or loss of hearing
  • Erection lasting more than 4 hours (priapism)

Common Side Effects - Talk to your provider if you experience:

  • Headache, flushing, indigestion, muscle aches, back pain, nasal congestion

Tadalafil has a Boxed Warning for embryo-fetal toxicity. Females must enroll in a special risk program before taking tadalafil products containing macitentan.

This is not a complete list of side effects. Refer to the full prescribing information. Report negative side effects to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.

Vardenafil

You must always read this safety information prior to starting this medication and whenever you get a refill. There may be new information. This information is not a substitute for discussing your medical condition or treatment with your healthcare provider. It is only available if prescribed by a licensed physician partner through BraveRx who will determine if treatment is suitable.

What I need to know about Vardenafil:

Vardenafil is a PDE5 inhibitor FDA-approved for treating erectile dysfunction (ED). It works by increasing blood flow to the penis.

Absolute Contraindications - DO NOT use vardenafil if you:

  • Are allergic to vardenafil
  • Are taking nitrate medications for angina or riociguat
  • Have phenylketonuria and are prescribed the rapidly disintegrating tablets (contain aspartame)
  • Have fructose intolerance and are prescribed the rapidly disintegrating tablets (contain sorbitol)

Drug Interactions - DO NOT use vardenafil if you take:

  • Nitrate medications like nitroglycerin or recreational "poppers"
  • Riociguat for pulmonary hypertension

Serious Side Effects - STOP treatment and seek emergency care if you experience:

  • Erection lasting more than 4 hours (priapism)
  • Sudden vision loss in one or both eyes
  • Sudden decrease or loss of hearing

Common Side Effects - Talk to your provider if you experience:

  • Headache, flushing, stuffy/runny nose, indigestion, back pain

Vardenafil may cause low blood pressure when taken with alpha-blockers for high blood pressure or BPH. It can also increase the blood pressure lowering effects of anti-hypertensives.

This is not a complete list of side effects. Refer to the full prescribing information. Report negative side effects to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.

Apomorphine

You must always read this safety information prior to starting this medication and whenever you get a refill. There may be new information. This information is not a substitute for discussing your medical condition or treatment with your healthcare provider. It is only available if prescribed by a licensed physician partner through BraveRx who will determine if treatment is suitable.

What I need to know about Apomorphine:

Apomorphine is a non-ergoline dopamine agonist FDA-approved for the acute intermittent treatment of "off" episodes associated with advanced Parkinson's disease.

Absolute Contraindications - DO NOT use apomorphine if you:

  • Are allergic to apomorphine, its ingredients, or sodium metabisulfite
  • Are taking 5HT3 antagonist anti-emetics like ondansetron, granisetron, etc.

Drug Interactions - DO NOT use apomorphine if you take:

  • 5HT3 antagonist anti-emetics like ondansetron, granisetron, dolasetron, palonosetron, alosetron

Serious Side Effects - STOP treatment and seek emergency care if you experience:

  • Severe nausea/vomiting, confusion, hallucinations
  • Low blood pressure, dizziness, fainting
  • Trouble breathing, chest pain

Common Side Effects - Talk to your provider if you experience:

  • Yawning, drowsiness, involuntary movements, runny nose, nausea

This is not a complete list of side effects. Refer to the full prescribing information. Report negative side effects to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.

L-Citrulline

You must always read this safety information prior to starting this medication and whenever you get a refill. There may be new information. This information is not a substitute for discussing your medical condition or treatment with your healthcare provider. It is only available if prescribed by a licensed physician partner through BraveRx who will determine if treatment is suitable.

What I need to know about L-Citrulline:

L-Citrulline is a non-essential amino acid used as a medical food for urea cycle disorders and sometimes taken as a dietary supplement.

Absolute Contraindications - DO NOT use L-citrulline if you:

  • Are allergic to L-citrulline

Drug Interactions - DO NOT use L-citrulline if you take:

  • Nitrate medications for heart disease
  • Blood pressure medications (may increase hypotensive effects)

Serious Side Effects - Seek medical care if you experience:

  • Severe drop in blood pressure, dizziness, fainting
  • Nausea, diarrhea, bloating, heartburn

Common Side Effects:

No major common side effects reported from studies using up to 9g/day for 16 days.

L-Citrulline has not been associated with serious safety concerns in studies but may interact with certain medications. Avoid use in pregnancy/breastfeeding due to lack of data.

This is not a complete list of side effects or interactions. Refer to the full product information. Report negative side effects to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.