Important Safety Information

Phosphodiesterase type 5 (PDE5) inhibitors are prescription medications used to treat erectile dysfunction by increasing blood flow to the penis during sexual stimulation. These medications do not cause an erection without sexual stimulation and are only available through prescription by a licensed healthcare provider.

Tadalafil

What I need to know about Tadalafil:

Tadalafil is a PDE5 inhibitor FDA-approved for the treatment of erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). It works by increasing blood flow to help achieve and maintain an erection when sexually stimulated.

Absolute Contraindications — DO NOT use tadalafil if you:

  • Are allergic to tadalafil or any of its ingredients
  • Are taking any form of nitrate medication for chest pain or heart conditions
  • Are taking guanylate cyclase stimulators such as riociguat

Drug Interactions — DO NOT use tadalafil if you take:

  • Nitrate medications including nitroglycerin, isosorbide, or recreational “poppers”
  • Guanylate cyclase stimulators such as riociguat
  • Certain HIV protease inhibitors or antifungal medications without provider guidance

Serious Side Effects — STOP treatment and seek emergency care if you experience:

  • Erection lasting more than 4 hours (priapism)
  • Sudden vision loss in one or both eyes
  • Sudden decrease or loss of hearing
  • Chest pain, severe dizziness, or fainting

Common Side Effects — Talk to your provider if you experience:

  • Headache
  • Flushing
  • Indigestion or upset stomach
  • Back pain or muscle aches
  • Nasal congestion

Tadalafil may cause a temporary drop in blood pressure, especially when taken with blood pressure medications or alpha-blockers.

Sildenafil

What I need to know about Sildenafil:

Sildenafil is a PDE5 inhibitor FDA-approved for the treatment of erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). It works by increasing blood flow to help achieve and maintain an erection when sexually stimulated.

Absolute Contraindications — DO NOT use sildenafil if you:

  • Are allergic to sildenafil or any of its ingredients
  • Are taking any form of nitrate medication for chest pain or heart conditions
  • Are taking guanylate cyclase stimulators such as riociguat

Drug Interactions — DO NOT use sildenafil if you take:

  • Nitrate medications including nitroglycerin, isosorbide, or recreational “poppers”
  • Guanylate cyclase stimulators such as riociguat
  • Certain HIV protease inhibitors or antifungal medications without provider guidance

Serious Side Effects — STOP treatment and seek emergency care if you experience:

  • Erection lasting more than 4 hours (priapism)
  • Sudden vision loss in one or both eyes
  • Sudden decrease or loss of hearing
  • Chest pain, severe dizziness, or fainting

Common Side Effects — Talk to your provider if you experience:

  • Headache
  • Flushing
  • Indigestion or upset stomach
  • Nasal congestion
  • Visual disturbances such as increased light sensitivity or color changes

Sildenafil may cause a temporary drop in blood pressure, especially when taken with blood pressure medications or alpha-blockers.

Vardenafil

What I need to know about Vardenafil:

Vardenafil is a PDE5 inhibitor FDA-approved for the treatment of erectile dysfunction (ED). It works by increasing blood flow to help achieve and maintain an erection when sexually stimulated.

Absolute Contraindications — DO NOT use vardenafil if you:

  • Are allergic to vardenafil or any of its ingredients
  • Are taking any form of nitrate medication for chest pain or heart conditions
  • Are taking guanylate cyclase stimulators such as riociguat
  • Have phenylketonuria (PKU) or fructose intolerance when prescribed rapidly disintegrating tablets

Drug Interactions — DO NOT use vardenafil if you take:

  • Nitrate medications including nitroglycerin, isosorbide, or recreational “poppers”
  • Guanylate cyclase stimulators such as riociguat

Serious Side Effects — STOP treatment and seek emergency care if you experience:

  • Erection lasting more than 4 hours (priapism)
  • Sudden vision loss in one or both eyes
  • Sudden decrease or loss of hearing
  • Chest pain, severe dizziness, or fainting

Common Side Effects — Talk to your provider if you experience:

  • Headache
  • Flushing
  • Indigestion or upset stomach
  • Back pain
  • Nasal congestion

Vardenafil may cause a temporary drop in blood pressure, especially when taken with blood pressure medications or alpha-blockers.

Apomorphine — Important Safety Information

Apomorphine is a prescription medication that acts as a non-ergoline dopamine agonist. It is FDA-approved for the acute, intermittent treatment of “off” episodes associated with advanced Parkinson’s disease and may be prescribed for other uses when clinically appropriate. Apomorphine is only available through prescription by a licensed healthcare provider.

What you need to know before using Apomorphine

Absolute Contraindications — DO NOT use apomorphine if you:

  • Are allergic to apomorphine or any of its ingredients, including sodium metabisulfite
  • Are taking 5-HT3 antagonist anti-emetic medications such as ondansetron, granisetron, dolasetron, palonosetron, or alosetron

Drug Interactions — DO NOT use apomorphine if you take:

  • Any 5-HT3 antagonist anti-emetic medications due to risk of severe hypotension and loss of consciousness

Serious Side Effects — STOP treatment and seek emergency care if you experience:

  • Severe or persistent nausea and vomiting
  • Confusion, hallucinations, or sudden changes in mental status
  • Significant drops in blood pressure, dizziness, or fainting
  • Trouble breathing, chest pain, or allergic reactions

Common Side Effects — Talk to your provider if you experience:

  • Drowsiness or sudden sleep episodes
  • Yawning
  • Nausea
  • Runny nose
  • Involuntary movements

Apomorphine may cause low blood pressure, sedation, or sudden sleep onset. Use caution when standing, driving, or operating machinery, especially when first starting treatment or adjusting dosage.

Important Apomorphine Disclaimer

This information does not include all possible side effects, interactions, or warnings. Apomorphine is not appropriate for everyone. Always follow your prescribing provider’s instructions and inform them of all medications, supplements, and medical conditions.

Report negative side effects to the FDA at www.fda.gov/medwatch or call 1-800-FDA-1088.